Comparar métodos
Revisa los métodos seleccionados uno junto a otro; las filas que difieren aparecen resaltadas.
| Ensamblaje de Transcritoma De Novo× | Búsqueda de Perfiles HMMER× | |
|---|---|---|
| Campo | Bioinformática | Bioinformática |
| Familia | Process / pipeline | Process / pipeline |
| Año de origen≠ | 2011 | 1994 |
| Autor original≠ | Aviv Regev | Sean Eddy |
| Tipo≠ | Sequence assembly pipeline | Probabilistic sequence search pipeline |
| Fuente seminal≠ | Grabherr, M. G., Haas, B. J., Yassour, M., Levin, J. Z., Thompson, D. A., Amit, I., ... & Regev, A. (2011). Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nature Biotechnology, 29(7), 644-652. DOI ↗ | Krogh, A., Brown, M., Mian, I. S., Sjölander, K., & Haussler, D. (1994). Hidden Markov models in computational biology: applications to protein modeling. Journal of Molecular Biology, 235(5), 1501-1531. DOI ↗ |
| Alias | transcriptome assembly, de novo assembly, RNA-Seq assembly | profile-hidden Markov model, HMM profile search, HMMER |
| Relacionados | 3 | 3 |
| Resumen≠ | De novo transcriptome assembly reconstructs full-length messenger RNA sequences directly from sequencing reads without requiring a reference genome. Pioneered by Regev, Haas, and colleagues, this pipeline enables transcript discovery in non-model organisms and detection of novel isoforms, fusion genes, and splice variants. | HMMER profile search identifies distant protein sequence homologs using probabilistic models of protein families, known as profile Hidden Markov Models (HMMs). Developed by Eddy and colleagues, this method captures sequence variation patterns within protein families and detects homologs with far greater sensitivity than position-weight matrices or pairwise alignment. |
| ScholarGateConjunto de datos ↗ |
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