Comparar métodos
Revisa los métodos seleccionados uno junto a otro; las filas que difieren aparecen resaltadas.
| Estudio adaptativo anidado de casos y controles× | Estudio de casos y controles anidado× | |
|---|---|---|
| Campo | Epidemiología | Epidemiología |
| Familia | Process / pipeline | Process / pipeline |
| Año de origen≠ | Base design 1977; adaptive extensions from 1990s onward | 1973–1977 |
| Autor original≠ | Nested case-control: D. C. Thomas (1977); adaptive design framework: Peter Bauer & Klaus Kohne (1994) | Nathan Mantel (1973); D. C. Thomas (1977 formalization) |
| Tipo≠ | Observational epidemiological study with adaptive design elements | Hybrid observational study design |
| Fuente seminal | Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. DOI ↗ | Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗ |
| Alias | adaptive NCC, adaptive nested case-referent study, dynamic nested case-control, sequential nested case-control | NCC study, nested CC design, case-control within cohort, density sampling case-control |
| Relacionados | 6 | 6 |
| Resumen≠ | An adaptive nested case-control study embeds a case-control comparison within a defined cohort and incorporates pre-specified interim decision rules that allow modifications — such as control-to-case ratio adjustment or biomarker sub-sampling revision — based on accumulating data, without compromising the study's validity or inflating type I error. The design combines the efficiency of the nested case-control framework with the flexibility of adaptive methodology to optimise resource use when exposure assessment is costly. | A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding. |
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