Methoden vergleichen

	Transmission Disequilibrium Test	QTL-Mapping
Fachgebiet	Genetik	Genetik
Familie	Process / pipeline	Process / pipeline
Entstehungsjahr	1993	1989
Urheber	Richard Spielman & Warren Ewens	Eric Lander & David Botstein
Typ	Hypothesis test	Genetic linkage method
Wegweisende Quelle	Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993). Transmission test for linkage disequilibrium. American Journal of Human Genetics, 52(3), 506–516.	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.
Aliasnamen	TDT, Family-based association test	QTL analysis, Linkage mapping, Trait locus mapping
Verwandt	4	4
Zusammenfassung	The Transmission Disequilibrium Test (TDT) is a family-based statistical method for testing genetic association with disease or traits while inherently controlling for population stratification. Developed by Spielman and Ewens in 1993, the TDT examines whether an allele is preferentially transmitted from heterozygous parents to affected children compared to unaffected children. By comparing transmission patterns within families, the TDT avoids the confounding effects of population structure that plague case-control studies, making it particularly valuable in admixed or stratified populations.	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.