Methoden vergleichen
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| Schild-Analyse× | Isobologrammanalyse× | |
|---|---|---|
| Fachgebiet | Pharmakologie | Pharmakologie |
| Familie | Process / pipeline | Process / pipeline |
| Entstehungsjahr≠ | 1947 | 1926 |
| Urheber≠ | Henry Schild | Salvatore Loewe |
| Typ≠ | antagonism quantification | synergy quantification |
| Wegweisende Quelle≠ | Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357. DOI ↗ | Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334. link ↗ |
| Aliasnamen≠ | Schild plot, pA2 | isobol, combination index, synergy testing |
| Verwandt | 3 | 3 |
| Zusammenfassung≠ | Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems. | Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic. |
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