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| Retrospektive Studie zur diagnostischen Genauigkeit× | Fall-Kontroll-Studie× | |
|---|---|---|
| Fachgebiet | Epidemiologie | Epidemiologie |
| Familie | Process / pipeline | Process / pipeline |
| Entstehungsjahr≠ | Formalized 2000s; STARD 2003, revised 2015 | 1950s (formal methodology); precursors in the 1920s |
| Urheber≠ | Formalized through the STARD initiative led by Patrick Bossuyt and colleagues | Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s |
| Typ≠ | Observational, retrospective study design | Observational analytic study design |
| Wegweisende Quelle≠ | Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., et al. (2015). STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies. BMJ, 351, h5527. DOI ↗ | Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860 |
| Aliasnamen | retrospective DAS, retrospective test accuracy study, retrospective index test evaluation, historical diagnostic accuracy study | case-referent study, case-control design, retrospective case-control, case-control analysis |
| Verwandt≠ | 5 | 6 |
| Zusammenfassung≠ | A retrospective diagnostic accuracy study evaluates how well a diagnostic test (the index test) correctly identifies a target condition by applying it to previously collected data or archived specimens alongside a reference standard. Because both index test results and reference standard results are drawn from existing records or stored material rather than generated prospectively, this design is faster and less costly than a prospective counterpart — but carries specific methodological risks that must be controlled to produce valid estimates of sensitivity, specificity, and related measures. | A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses. |
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