Methoden vergleichen

	QTL-Mapping	IBD-Mapping
Fachgebiet	Genetik	Genetik
Familie	Process / pipeline	Process / pipeline
Entstehungsjahr	1989	1987
Urheber	Eric Lander & David Botstein	Eric Lander & David Botstein
Typ	Genetic linkage method	Genomic mapping method
Wegweisende Quelle	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.	Lander, E. S., & Botstein, D. (1987). Homozygosity mapping of autosomal recessive disorders in consanguineous families. American Journal of Human Genetics, 36(3), 537–551.
Aliasnamen	QTL analysis, Linkage mapping, Trait locus mapping	IBD mapping, Autozygosity mapping, Homozygosity mapping
Verwandt	4	4
Zusammenfassung	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.	Identity-by-descent (IBD) mapping is a genetic mapping technique that identifies disease loci in consanguineous families or isolated populations by detecting homozygous chromosomal segments shared among affected individuals. Developed by Lander and Botstein in 1987, this method exploits the fact that rare disease alleles in related individuals must lie within shared ancestral DNA blocks. By mapping regions where affected individuals are homozygous at multiple markers, researchers can localize disease genes to narrowly defined genomic intervals without prior knowledge of the disease mechanism.