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| Physiologisch basierte Pharmakokinetik× | Michaelis-Menten-Kinetik× | |
|---|---|---|
| Fachgebiet | Pharmakologie | Pharmakologie |
| Familie | Process / pipeline | Process / pipeline |
| Entstehungsjahr≠ | 1997 | 1913 |
| Urheber≠ | Ivan Nestorov | Leonor Michaelis and Maud Menten |
| Typ≠ | predictive modeling | mechanistic model |
| Wegweisende Quelle≠ | Nestorov, I. (1997). Sensitivity analysis of pharmacokinetic and pharmacodynamic systems. Journal of Pharmacokinetics and Biopharmaceutics, 25(4), 529-543. link ↗ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ |
| Aliasnamen≠ | PBPK, PBPK modeling | MM kinetics, Michaelis constant, Vmax |
| Verwandt≠ | 3 | 2 |
| Zusammenfassung≠ | PBPK is a mechanistic modeling framework that uses physiological parameters, tissue properties, and drug-specific attributes to predict drug concentration time profiles in the body. Developed rigorously in the 1990s by researchers including Nestorov, PBPK integrates anatomy, biochemistry, and kinetics to enable rational drug development, bridging in vitro data to clinical outcomes. | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. |
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