Methoden vergleichen

	Phylogenetische Analyse	eQTL-Analyse
Fachgebiet	Bioinformatik	Bioinformatik
Familie	Process / pipeline	Process / pipeline
Entstehungsjahr	1960s-1981 (distance trees ~1967; ML framework formalised 1981)	2001 (term coined); widely adopted after 2005
Urheber	Joseph Felsenstein (maximum likelihood framework); Walter Fitch and Emanuel Margoliash (distance methods)	Ritsert C. Jansen & Jan-Peter Nap
Typ	Computational inference method	Association mapping method
Wegweisende Quelle	Felsenstein, J. (2004). Inferring Phylogenies. Sinauer Associates. ISBN: 978-0878931774	Jansen, R. C., & Nap, J.-P. (2001). Genetical genomics: the added value from segregation. Trends in Genetics, 17(7), 388–391.
Aliasnamen	molecular phylogenetics, phylogenetic inference, evolutionary tree reconstruction, phylogenomics	eQTL mapping, expression QTL analysis, transcriptomic QTL analysis, eQTL study
Verwandt	5	6
Zusammenfassung	Phylogenetic analysis reconstructs the evolutionary history of organisms, genes, or proteins by comparing molecular sequence data and estimating the branching tree that best explains observed similarities and differences. Rooted in the work of Felsenstein and colleagues from the 1960s onward, it is a cornerstone technique in evolutionary biology, microbiology, epidemiology, and comparative genomics, supporting tasks from tracing viral outbreak origins to classifying novel species.	eQTL analysis identifies genomic loci (variants, typically SNPs) whose genotype statistically associates with variation in the expression level of one or more genes. By jointly profiling DNA-level variation and RNA-level expression in the same individuals, eQTL studies decode the regulatory grammar of the genome — revealing which variants control how much a gene is transcribed, in which tissues, and under what conditions.