Methoden vergleichen

	Magnetisierungstransfer-Verhältnis	Diffusion-Kurtosis-Bildgebung	NODDI	Tract-Based Spatial Statistics
Fachgebiet	Neurobildgebung	Neurobildgebung	Neurobildgebung	Neurobildgebung
Familie	Process / pipeline	Process / pipeline	Process / pipeline	Process / pipeline
Entstehungsjahr	1989	2005	2012	2006
Urheber	Stephen Wolff	Jens Jensen	Hui Zhang	Stephen M. Smith
Typ	Tissue microstructure characterization	Microstructural white matter analysis	Microstructural white matter mapping	Diffusion MRI white matter analysis pipeline
Wegweisende Quelle	Wolff, S. D., & Balaban, R. S. (1989). Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Journal of Magnetic Resonance Imaging, 10(2), 135–148.	Jensen, J. H., Helpern, J. A., Ramani, A., et al. (2005). Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by magnetic resonance imaging. Magnetic Resonance in Medicine, 53(6), 1432–1440.	Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012). NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage, 61(4), 1000–1016.	Smith, S. M., Jenkinson, M., Johansen-Berg, H., et al. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage, 31(4), 1487–1505.
Aliasnamen	MTR, magnetization transfer, MT imaging	DKI, non-Gaussian diffusion, diffusion kurtosis	NODDI, neurite density mapping	TBSS, white matter skeleton analysis
Verwandt	3	3	3	3
Zusammenfassung	Magnetisation Transfer Ratio (MTR) is an MRI method that measures the exchange of magnetization between free water protons and protons bound to macromolecules (primarily myelin lipids and proteins). Introduced by Wolff and Balaban in 1989, MTR reflects tissue macromolecular content and is particularly sensitive to myelination, providing a non-invasive estimate of myelin density.	Diffusion Kurtosis Imaging (DKI) is an advanced diffusion MRI technique that quantifies non-Gaussian diffusion of water molecules, providing detailed information about tissue microstructure beyond conventional diffusion tensor imaging. Introduced by Jensen and colleagues in 2005, DKI detects deviations from normal Gaussian diffusion, revealing information about cellular compartmentalization and fiber heterogeneity.	Neurite Orientation Dispersion and Density Imaging (NODDI) is a biophysical diffusion MRI model that quantifies microstructural properties of white matter: neurite density (axonal density), orientation dispersion (fiber coherence), and isotropic diffusion (free water or cerebrospinal fluid). Introduced by Zhang and colleagues in 2012, NODDI provides biologically interpretable metrics directly linking diffusion MRI signals to tissue microstructure.	Tract-Based Spatial Statistics (TBSS) is a voxel-wise analysis method for detecting group differences in white matter microstructure from diffusion MRI data. Published by Stephen M. Smith and colleagues in 2006, TBSS addresses registration and multiple comparison problems inherent in voxel-wise analysis by projecting individual FA maps onto a white matter skeleton derived from a population template.