Methoden vergleichen

	Isobologrammanalyse	Populationspharmakodynamische Modellierung	Schild-Analyse
Fachgebiet	Pharmakologie	Pharmakologie	Pharmakologie
Familie	Process / pipeline	Process / pipeline	Process / pipeline
Entstehungsjahr	1926	1992	1947
Urheber	Salvatore Loewe	Lewis Sheiner and Stephen Roush	Henry Schild
Typ	synergy quantification	dose-response modeling	antagonism quantification
Wegweisende Quelle	Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334.	Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57.	Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357.
Aliasnamen	isobol, combination index, synergy testing	PopPD, population PD, hierarchical PD modeling	Schild plot, pA2
Verwandt	3	3	3
Zusammenfassung	Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic.	Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction.	Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems.