Methoden vergleichen

	Bland-Altman-Methode Vergleichsanalyse	Äquivalenztest (TOST
Fachgebiet	Statistik	Statistik
Familie	Hypothesis test	Hypothesis test
Entstehungsjahr	1986	1987
Urheber	J. Martin Bland & Douglas G. Altman	Donald J. Schuirmann
Typ	Graphical and statistical method comparison	Parametric equivalence test
Wegweisende Quelle	Bland, J.M. & Altman, D.G. (1986). Statistical Methods for Assessing Agreement Between Two Methods of Clinical Measurement. Lancet, 327(8476), 307–310.	Schuirmann, D.J. (1987). A Comparison of the Two One-Sided Tests Procedure and the Power Approach for Assessing the Equivalence of Average Bioavailability. Journal of Pharmacokinetics and Biopharmaceutics, 15(6), 657–680.
Aliasnamen	Bland-Altman plot, limits of agreement analysis, method agreement analysis, Bland-Altman Uyum Analizi	TOST, two one-sided tests, bioequivalence test, Eşdeğerlik Testi (TOST — Two One-Sided Tests)
Verwandt	5	5
Zusammenfassung	The Bland-Altman analysis is a graphical and statistical technique for assessing agreement between two measurement methods applied to the same subjects. Introduced by J. Martin Bland and Douglas G. Altman in their landmark 1986 Lancet paper, it plots the difference between the two methods against their mean for each subject, and derives the bias (mean difference) along with limits of agreement (LoA) that capture 95% of differences in the population.	The equivalence test using the Two One-Sided Tests (TOST) procedure is a parametric hypothesis test designed to demonstrate that the difference between two group means falls within a pre-specified equivalence region ±Δ. Introduced by Schuirmann (1987) in the context of pharmaceutical bioequivalence, TOST reverses the logic of classical null-hypothesis testing: instead of trying to detect a difference, it provides positive evidence of similarity.