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| Bayesian Metabolomics Analysis× | Metabolomics Analysis× | |
|---|---|---|
| Fachgebiet | Bioinformatik | Bioinformatik |
| Familie | Process / pipeline | Process / pipeline |
| Entstehungsjahr≠ | 2005–2010 | 1998–2002 |
| Urheber≠ | Simon Rogers, Mark Girolami and colleagues (Bayesian NMR metabolomics framework, ~2009); broader Bayesian metabolomics developed through 2000s–2010s | Oliver et al. (coining of 'metabolomics'); Oliver Fiehn (systematic framework) |
| Typ≠ | Probabilistic statistical pipeline | Quantitative omics pipeline |
| Wegweisende Quelle≠ | Rogers, S., Scheltema, R. A., & Girolami, M. A. (2009). Bayesian analysis of metabolomic NMR data. Bioinformatics, 25(14), 1809-1815. link ↗ | Fiehn, O. (2002). Metabolomics — the link between genotypes and phenotypes. Plant Molecular Biology, 48(1-2), 155–171. link ↗ |
| Aliasnamen | Bayesian metabolomics, probabilistic metabolomics, Bayesian metabolite profiling, Bayesian metabolic flux analysis | metabolome profiling, metabolic profiling, metabonomics, metabolite profiling |
| Verwandt | 6 | 6 |
| Zusammenfassung≠ | Bayesian metabolomics analysis applies probabilistic inference to metabolite abundance data — typically from mass spectrometry or NMR spectroscopy — to identify differentially abundant metabolites, annotate spectral features, and integrate pathway knowledge. By encoding prior biological knowledge into prior distributions and propagating uncertainty throughout the analysis, it yields more calibrated probability statements about metabolic differences than classical frequentist testing alone. | Metabolomics analysis is the large-scale, systematic measurement of small-molecule metabolites in a biological sample to characterise the metabolome — the complete set of metabolic intermediates and products present under defined conditions. By coupling high-throughput analytical platforms such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy with multivariate statistics and pathway databases, metabolomics bridges the genotype–phenotype gap and captures the downstream functional output of genes, transcripts, and proteins in real time. |
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