Methoden vergleichen

	Adaptives Laborexperiment	Sequenzielle Analyse (Gruppensequenzielle Planung)
Fachgebiet	Versuchsplanung	Statistik
Familie	Process / pipeline	Hypothesis test
Entstehungsjahr	1947 (sequential analysis foundations); adaptive laboratory applications widespread from 1990s	1977
Urheber	Rooted in sequential analysis (Abraham Wald, 1947); adaptive clinical/lab designs formalized by Berry and colleagues (1990s–2000s)	P. C. O'Brien & T. R. Fleming; P. C. Pocock
Typ	Adaptive experimental design	Sequential / adaptive hypothesis test
Wegweisende Quelle	Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36.	O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556.
Aliasnamen	adaptive lab experiment, sequential adaptive laboratory study, response-adaptive laboratory design, adaptive experimental laboratory design	sequential testing, group sequential design, interim analysis, Sıralı Analiz (Sequential Testing / Group Sequential Design)
Verwandt	5	5
Zusammenfassung	An adaptive laboratory experiment is a controlled experimental design conducted in a laboratory setting where pre-specified decision rules allow modifications to the study — such as sample size, treatment allocation, or stopping criteria — based on accumulating data. Unlike fixed designs, adaptive designs incorporate planned interim analyses that permit the experiment to respond to emerging evidence while maintaining statistical validity and Type I error control.	Sequential analysis is a framework for conducting hypothesis tests with pre-planned interim looks at accumulating data, allowing a study to stop early for efficacy or futility while controlling the overall Type I error rate. The group sequential approach was formalised by Pocock (1977) and O'Brien and Fleming (1979), and remains the standard for confirmatory clinical trials and rigorous A/B experiments.