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| Adaptives Experiment× | Randomisierte kontrollierte Studie (RCT)× | |
|---|---|---|
| Fachgebiet | Versuchsplanung | Versuchsplanung |
| Familie≠ | Process / pipeline | Hypothesis test |
| Entstehungsjahr≠ | 1940s–1970s (sequential foundations); formalised in clinical and behavioural research by 1980s–2000s | 1948 |
| Urheber≠ | Abraham Wald (sequential analysis foundation); expanded by Robbins, Armitage, and others | James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948) |
| Typ≠ | Experimental research design | Interventional comparative study |
| Wegweisende Quelle≠ | Chow, S. C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman and Hall/CRC. ISBN: 978-1584886761 | Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332. DOI ↗ |
| Aliasnamen | adaptive design, response-adaptive randomization, adaptive trial, adaptive randomization | RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı |
| Verwandt≠ | 5 | 7 |
| Zusammenfassung≠ | An adaptive experiment is an experimental design in which pre-specified rules allow the protocol to be modified — such as reallocating participants to better-performing arms, stopping early for efficacy or futility, or changing sample size — based on accumulating interim data, while maintaining statistical validity. Adaptive designs are widely used in clinical trials, behavioural economics, and online platform testing to improve efficiency and ethics without sacrificing inferential rigour. | A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010). |
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