Pragmatic Fractional Factorial Experiment
A pragmatic fractional factorial experiment applies fractional factorial design principles to real-world or clinical intervention research, enabling simultaneous evaluation of multiple intervention components in a resource-efficient fraction of the full factorial runs. Popularised through the Multiphase Optimization Strategy (MOST), it identifies which components of a multi-component intervention contribute meaningfully to outcomes before a confirmatory randomized trial is conducted.
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- Collins, L. M., Murphy, S. A., & Strecher, V. (2007). The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): New methods for more potent eHealth interventions. American Journal of Preventive Medicine, 32(5S), S112–S118. · DOI 10.1016/j.amepre.2007.01.022
- Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. · ISBN 978-1119492443
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