Network Motif Analysis
Network motif analysis is a statistical method for directed networks, introduced by Milo, Shen-Orr, and Alon in 2002, that identifies small recurring subgraph patterns — motifs — that appear significantly more often than would be expected in a comparable random network. By comparing a real network against a null ensemble of randomised graphs, the method reveals the elementary structural building blocks that define the functional organisation of biological regulatory networks, social networks, and other complex systems.
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- Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., & Alon, U. (2002). Network Motifs: Simple Building Blocks of Complex Networks. Science, 298(5594), 824-827. · DOI 10.1126/science.298.5594.824
- Alon, U. (2007). Network Motifs: Theory and Experimental Approaches. Nature Reviews Genetics, 8(6), 450-461. · DOI 10.1038/nrg2102
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