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| Risikojusteret case-crossover design× | Propensity Score Matching× | |
|---|---|---|
| Fagområde≠ | Epidemiologi | Forskningsstatistik |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | 1991 (base design); risk-adjustment extensions from mid-1990s onward | 1983 |
| Ophavsperson≠ | Malcolm Maclure (case-crossover base); extensions incorporating covariate risk adjustment developed in subsequent pharmacoepidemiology literature | Paul Rosenbaum and Donald Rubin |
| Type≠ | Observational analytic epidemiological design | Method |
| Oprindelig kilde≠ | Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ | Rosenbaum, P. R., & Rubin, D. B. (1983). The central role of the propensity score in observational studies for causal effects. Biometrika, 70(1), 41–55. DOI ↗ |
| Aliasser≠ | adjusted case-crossover study, covariate-adjusted case-crossover, risk-controlled case-crossover, case-crossover with risk adjustment | PSM, propensity score weighting, covariate balance |
| Relaterede≠ | 4 | 3 |
| Resumé≠ | The risk-adjusted case-crossover design is a self-matched epidemiological method that compares a person's exposure during a brief hazard window immediately preceding an acute event to their exposure during one or more control windows from the same individual, while formally accounting for time-varying or time-fixed covariates that could confound the exposure-event relationship. By using each case as their own control, stable individual-level confounders are automatically cancelled, while covariate adjustment handles residual time-varying risks. | Propensity score matching (PSM) is a method for reducing confounding bias in observational studies by balancing baseline characteristics between treatment groups, simulating randomization. Developed by Rosenbaum and Rubin (1983), it estimates the probability of receiving treatment given observed covariates, then matches or weights treated and control individuals with similar treatment probabilities. Widely used in medicine, epidemiology, and policy evaluation when randomized trials are infeasible or unethical, enabling estimation of treatment effects while controlling for selection bias. |
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