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MSFC: Multiple Sclerosis Functional Composite×EDSS: Kurtzke Expanded Disability Status Scale×MDS-UPDRS×RMI: Rivermead Mobility Index×
FagområdeNeurologiNeurologiNeurologiNeurologi
FamilieProcess / pipelineProcess / pipelineProcess / pipelineProcess / pipeline
Oprindelsesår1999198320081991
OphavspersonGary Cutter, Richard Rudick, and NMSS ConsortiumJohn F. KurtzkeChristopher G. Goetz and Movement Disorder SocietyFrank Collen, Derick Wade, and Rivermead Rehabilitation Centre
TypeClinician-administered performance testClinician-ratedClinician-ratedClinician-observed performance test
Oprindelig kildeCutter, G. R., Baier, M. L., Rudick, R. A., et al. (1999). Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Multiple Sclerosis, 5(4), 244-250. DOI ↗Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33(11), 1444-1452. DOI ↗Goetz, C. G., et al. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170. DOI ↗Collen, F. M., Wade, D. T., Robb, G. F., Bradshaw, C. M. (1991). The Rivermead Mobility Index: A further development of the Rivermead Motor Assessment. International Disability Studies, 13(2), 50-54. DOI ↗
AliasserMS Functional CompositeExpanded Disability Status ScaleUPDRSRivermead Mobility Index
Relaterede4455
ResuméThe Multiple Sclerosis Functional Composite (MSFC) is an objective, performance-based assessment of MS-related disability capturing three key functional domains: lower extremity mobility, upper extremity coordination, and cognitive/processing speed. Developed in 1999 by the National MS Society and adopted widely in clinical trials, the MSFC provides quantifiable endpoints complementing the Expanded Disability Status Scale (EDSS). The three-component design addresses EDSS limitations by including cognition and standardizing measurement via timed tasks.The EDSS is the most widely used clinical disability rating scale in multiple sclerosis research and practice. Developed by John Kurtzke in 1983, it provides a 0-10 ordinal scale capturing disease severity across eight neurological functional systems and functional status. The EDSS remains the primary endpoint in MS clinical trials and longitudinal cohort studies, with decades of prognostic and comparative data worldwide.The MDS-UPDRS is the gold-standard clinician-administered rating scale for assessing motor and non-motor manifestations of Parkinson's disease. Developed by the Movement Disorder Society in 2008 to enhance the original UPDRS, it measures disease severity across daily living, motor function, and treatment complications. Used globally in clinical trials, longitudinal cohort studies, and routine neurological practice.The Rivermead Mobility Index (RMI) is a brief, clinician-observed performance test of basic mobility abilities developed for assessing stroke and neurological rehabilitation outcomes. Published in 1991 by Frank Collen and colleagues at Rivermead Rehabilitation Centre (Oxford, UK), the 15-item index measures bed mobility, sitting/standing balance, transfers, and ambulation. The RMI is widely used in stroke units and rehabilitation settings to track functional recovery and predict discharge outcomes.
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ScholarGateSammenlign metoder: MSFC · EDSS · MDS-UPDRS · RMI. Hentet 2026-06-19 fra https://scholargate.app/da/compare