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| Matched Case-Kontrol Studie× | Case-Crossover Design× | |
|---|---|---|
| Fagområde | Epidemiologi | Epidemiologi |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | 1950s–1970s | 1991 |
| Ophavsperson≠ | Brian MacMahon and others; systematised by Schlesselman (1982) | Malcolm Maclure |
| Type≠ | Observational analytic design | Observational epidemiological study design |
| Oprindelig kilde≠ | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755474 | Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ |
| Aliasser | matched case-referent study, individually matched case-control, pair-matched case-control, matched case-control design | case-crossover study, CCO design, self-matched case study, within-person crossover case study |
| Relaterede≠ | 5 | 3 |
| Resumé≠ | A matched case-control study is an observational epidemiological design in which each case (a person with the disease or outcome of interest) is paired with one or more controls (persons without the outcome) who share one or more characteristics — such as age, sex, or clinical setting — to control confounding. Exposure history is then compared between cases and their matched controls to estimate the odds ratio of the exposure-disease association. | The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury. |
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