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Crossover Multi-Arm Eksperiment×Latin Square og Greco-Latin Square Design×
FagområdeForsøgsdesignForsøgsdesign
FamilieProcess / pipelineHypothesis test
OprindelsesårMid-20th century; multi-arm extensions formalized by 1970s–1980s1935
OphavspersonDeveloped from early crossover trial methodology (Williams 1949; Cochran & Cox 1957)Ronald A. Fisher
TypeWithin-subject experimental design with multiple treatment armsParametric blocked ANOVA
Oprindelig kildeJones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584883869Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119492443
Aliassermulti-arm crossover trial, multi-period multi-treatment crossover, CMAT, multi-treatment crossover experimentLatin Square, Greco-Latin Square, Latin Kare ve Greco-Latin Kare Deseni
Relaterede55
ResuméA crossover multi-arm experiment is a within-subject experimental design in which each participant receives three or more treatments (arms) across successive periods, with random assignment to sequence. Because every participant experiences all arms, the design eliminates between-subject variability from treatment comparisons, dramatically increasing statistical power for a given sample size. It is widely used in clinical pharmacology, psychology, agriculture, and behavioral research.The Latin square design is a blocked experimental design that simultaneously controls two independent nuisance factors — the row block and the column block — so that each treatment appears exactly once in every row and every column of an n×n arrangement. Formalised by Ronald A. Fisher in his 1935 monograph The Design of Experiments, the design dramatically reduces experimental error by absorbing variation from two extraneous sources before the treatment effects are estimated.
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ScholarGateSammenlign metoder: Crossover multi-arm experiment · Latin Square Design. Hentet 2026-06-18 fra https://scholargate.app/da/compare