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| Crossover Full Factorial Experiment× | Crossover Randomiseret Kontrolleret Forsøg× | |
|---|---|---|
| Fagområde | Forsøgsdesign | Forsøgsdesign |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | Mid-to-late 20th century (crossover trials formalised ~1960s–1980s; full factorial DoE from Fisher ~1935) | 1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s |
| Ophavsperson≠ | Developed within the design-of-experiments tradition (R. A. Fisher and successors); crossover adaptation formalised by B. Jones and M. G. Kenward | Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002) |
| Type≠ | Within-subject full factorial experimental design | Experimental within-subject design |
| Oprindelig kilde≠ | Jones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584883429 | Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533 |
| Aliasser | within-subject full factorial design, repeated-measures full factorial experiment, crossover factorial trial, full factorial crossover design | crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design |
| Relaterede≠ | 6 | 5 |
| Resumé≠ | A crossover full factorial experiment combines the efficiency of a crossover (within-subject) design with the comprehensiveness of a full factorial design. Every participant receives all combinations of the factor levels across successive treatment periods, separated by washout intervals, allowing complete estimation of all main effects and interactions while using each participant as their own control. | A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size. |
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