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| Crossover Kontrolgruppe Eksperimentelt Design× | Crossover Randomiseret Kontrolleret Forsøg× | |
|---|---|---|
| Fagområde | Forsøgsdesign | Forsøgsdesign |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | Mid-20th century; systematic treatment from 1980s onward | 1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s |
| Ophavsperson≠ | Established in clinical pharmacology and agricultural research; formalized by B. Jones & M. G. Kenward | Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002) |
| Type≠ | Experimental design | Experimental within-subject design |
| Oprindelig kilde≠ | Jones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584883500 | Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533 |
| Aliasser | crossover controlled trial, within-subject crossover with control, AB/BA crossover controlled design, repeated-measures crossover with control arm | crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design |
| Relaterede≠ | 6 | 5 |
| Resumé≠ | A crossover control group experimental design is an experimental approach in which participants are randomly assigned to sequences of conditions that include both a treatment and a control (no-treatment or placebo) period, with each participant experiencing both the experimental and control conditions in succession. By using each participant as their own control across periods, this design sharply reduces between-subject variability and typically requires fewer participants than parallel group trials to achieve equivalent statistical power. | A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size. |
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