পদ্ধতির তুলনা করুন

	Prospective Randomized Clinical Trial	প্র্যাগম্যাটিক র‍্যান্ডমাইজড ক্লিনিক্যাল ট্রায়াল
ক্ষেত্র	মহামারীবিদ্যা	মহামারীবিদ্যা
পরিবার	Process / pipeline	Process / pipeline
উদ্ভবের বছর	1948 (landmark MRC streptomycin trial)	1967
প্রবর্তক	Austin Bradford Hill / Medical Research Council	Daniel Schwartz & Joseph Lellouch
ধরন	Experimental / interventional study design	Interventional study design
মৌলিক উৎস	Medical Research Council (1948). Streptomycin treatment of pulmonary tuberculosis: a Medical Research Council investigation. British Medical Journal, 2(4582), 769–782.	Schwartz, D., & Lellouch, J. (1967). Explanatory and pragmatic attitudes in therapeutical trials. Journal of Chronic Diseases, 20(8), 637–648.
অপর নাম	Prospective RCT, randomized controlled trial, RCT, controlled clinical trial	pragmatic RCT, effectiveness trial, real-world RCT, practical clinical trial
সম্পর্কিত	5	6
সারসংক্ষেপ	A prospective randomized clinical trial (RCT) is an experimental study in which participants are assigned to intervention or control groups by chance before any outcomes are observed, then followed forward in time. Random allocation eliminates systematic selection bias, making this design the gold standard for establishing causal efficacy of treatments in medicine and clinical research.	A pragmatic randomized clinical trial (pragmatic RCT) is an interventional study that tests whether a treatment works under routine clinical conditions, as opposed to the tightly controlled setting of an explanatory trial. It prioritizes broad eligibility, flexible delivery, and patient-relevant outcomes to answer the question 'Does this treatment work in everyday practice?' rather than 'Can this treatment work under ideal circumstances?' The distinction between pragmatic and explanatory trials was formally articulated by Schwartz and Lellouch in 1967 and operationalized by the PRECIS tool in 2009.