পদ্ধতির তুলনা করুন
নির্বাচিত পদ্ধতিগুলো পাশাপাশি পর্যালোচনা করুন; যে সারিগুলোয় পার্থক্য আছে সেগুলো চিহ্নিত করা হয়।
| মাল্টি-ওমিক্স এপিজিনোম-ওয়াইড অ্যাসোসিয়েশন স্টাডি× | জিনোম-ওয়াইড অ্যাসোসিয়েশন স্টাডি (GWAS)× | |
|---|---|---|
| ক্ষেত্র | জৈব তথ্যবিজ্ঞান | জৈব তথ্যবিজ্ঞান |
| পরিবার | Process / pipeline | Process / pipeline |
| উদ্ভবের বছর≠ | 2011 (EWAS foundation); multi-omics integration ~2015–2020 | 2005–2007 |
| প্রবর্তক≠ | Rakyan, Down, Balding & Beck (EWAS framework); multi-omics integration extended by multiple groups (~2015–2020) | Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007) |
| ধরন≠ | Integrative association study | Observational genomic association study |
| মৌলিক উৎস≠ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. DOI ↗ | Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661–678. link ↗ |
| অপর নাম | multi-omics EWAS, integrative EWAS, multi-layer epigenome-wide association, multi-omics epigenomic integration | GWAS, genome-wide association analysis, whole-genome association study, WGAS |
| সম্পর্কিত≠ | 4 | 6 |
| সারসংক্ষেপ≠ | A multi-omics epigenome-wide association study (multi-omics EWAS) systematically scans the entire epigenome — typically DNA methylation at CpG sites — for associations with a phenotype of interest, then integrates findings across additional omics layers such as transcriptomics, genomics, proteomics, or metabolomics. By linking epigenetic variation to molecular changes at multiple biological levels simultaneously, this approach identifies regulatory mechanisms and biomarkers that single-omics EWAS cannot resolve. | A genome-wide association study (GWAS) systematically tests hundreds of thousands to millions of single-nucleotide polymorphisms (SNPs) across the human genome for statistical association with a trait or disease. By comparing allele frequencies between cases and controls — or by regressing SNP genotypes on a quantitative phenotype — GWAS identifies genomic loci that harbor common genetic variants contributing to complex traits. Since its large-scale debut in 2007, GWAS has catalogued thousands of robust disease–variant associations across virtually every common human condition. |
| ScholarGateডেটাসেট ↗ |
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