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| Анализ на Schild× | Популационно фармакодинамично моделиране× | |
|---|---|---|
| Област | Фармакология | Фармакология |
| Семейство | Process / pipeline | Process / pipeline |
| Година на възникване≠ | 1947 | 1992 |
| Създател≠ | Henry Schild | Lewis Sheiner and Stephen Roush |
| Тип≠ | antagonism quantification | dose-response modeling |
| Основополагащ източник≠ | Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357. DOI ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| Други названия≠ | Schild plot, pA2 | PopPD, population PD, hierarchical PD modeling |
| Свързани | 3 | 3 |
| Резюме≠ | Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
| ScholarGateНабор от данни ↗ |
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