Сравнение на методи

	Картографиране на количествени локуси (QTL)	Анализ на блокове на неравновесие по свързване (LD)
Област	Генетика	Генетика
Семейство	Process / pipeline	Process / pipeline
Година на възникване	1989	2002
Създател	Eric Lander & David Botstein	Shaun Gabriel & Eric Lander
Тип	Genetic linkage method	Haplotype analysis method
Основополагащ източник	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.	Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229.
Други названия	QTL analysis, Linkage mapping, Trait locus mapping	Haplotype block analysis, LD mapping, Block structure analysis
Свързани	4	5
Резюме	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.	Linkage disequilibrium (LD) block analysis is a genomic method that partitions the human genome into distinct haplotype blocks—regions of limited recombination where variants are in strong statistical association. First systematically described by Gabriel and colleagues in 2002, this approach reveals the underlying structure of genetic variation and enables efficient genomic studies by reducing the number of variants needed to capture common diversity. LD block analysis forms the foundation of genome-wide association study (GWAS) design and modern population genetics.