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| Проспективен дизайн случай-контрола× | Проспективно кохортно проучване× | |
|---|---|---|
| Област | Епидемиология | Епидемиология |
| Семейство | Process / pipeline | Process / pipeline |
| Година на възникване≠ | 1991 (base design); prospective variant described in late 1990s–2000s | 1950s (systematic application); conceptual roots earlier |
| Създател≠ | Malcolm Maclure (case-crossover concept); prospective variant established by subsequent methodologists including Navidi and Weinhandl | Richard Doll and Austin Bradford Hill (landmark application, 1951-1954); cohort methodology formalised by modern epidemiology textbooks |
| Тип≠ | Observational epidemiological study design | Observational longitudinal study design |
| Основополагащ източник≠ | Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641 |
| Други названия | prospective case-crossover study, forward-looking case-crossover, prospective self-controlled case-crossover, real-time case-crossover | longitudinal cohort study, prospective follow-up study, incidence study, prospective observational cohort |
| Свързани≠ | 3 | 6 |
| Резюме≠ | The prospective case-crossover design is an observational epidemiological study in which each case serves as their own control. Unlike the retrospective variant, exposures are recorded in real time as participants are followed forward, eliminating recall bias. It is particularly suited to investigating transient environmental or behavioral triggers of acute events such as myocardial infarction, asthma attacks, or road-traffic injuries. | A prospective cohort study assembles a group of participants who are free of the outcome of interest at baseline, measures their exposures, and then follows them forward in time to record who develops the outcome. By collecting exposure data before outcomes occur, it establishes a clear temporal sequence that supports causal inference — a major advantage over retrospective designs. It is the cornerstone observational method in epidemiology and clinical research. |
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