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| Мета-аналитичен нестет случай-контрола× | Вложено проучване "случай-контрола"× | |
|---|---|---|
| Област | Епидемиология | Епидемиология |
| Семейство | Process / pipeline | Process / pipeline |
| Година на възникване≠ | 1980s–2000s | 1973–1977 |
| Създател≠ | Synthesis of Mantel-Haenszel methods and nested case-control design; formal pooling frameworks developed by Rothman, Greenland, and collaborative groups (e.g., IARC) through the 1980s–2000s | Nathan Mantel (1973); D. C. Thomas (1977 formalization) |
| Тип≠ | Quantitative epidemiological synthesis | Hybrid observational study design |
| Основополагащ източник≠ | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641 | Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗ |
| Други названия | MNCC, pooled nested case-control, meta-analysis of nested case-control studies, nested case-control meta-analysis | NCC study, nested CC design, case-control within cohort, density sampling case-control |
| Свързани≠ | 2 | 6 |
| Резюме≠ | Meta-analytic nested case-control analysis combines the efficiency advantages of the nested case-control design — in which cases and matched controls are sampled from a defined cohort — with the statistical power and generalisability gained by pooling estimates from multiple such studies. This approach is especially valuable in chronic-disease epidemiology where individual studies are often underpowered to detect modest exposure-outcome associations. | A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding. |
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