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| Епигеномно-широк анализ на асоциации (EWAS) в образователните изследвания× | Медиационен анализ× | |
|---|---|---|
| Област≠ | Биоинформатика | Статистика |
| Семейство≠ | Process / pipeline | Hypothesis test |
| Година на възникване≠ | EWAS framework ~2011; educational applications ~2017–present | 1986 |
| Създател≠ | Rakyan, Down, Balding, and Beck (framework); applied to educational outcomes by Marioni, McCartney, and collaborators | Baron & Kenny |
| Тип≠ | Observational epigenomic association design | Indirect effects / path test |
| Основополагащ източник≠ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. DOI ↗ | Baron, R. M. & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research. Journal of Personality and Social Psychology, 51(6), 1173–1182. link ↗ |
| Други названия | EWAS of educational attainment, educational EWAS, epigenetic association study, EWAS | indirect effects analysis, path-based mediation, PROCESS macro mediation, Aracılık Analizi (Mediation / PROCESS) |
| Свързани≠ | 3 | 5 |
| Резюме≠ | An epigenome-wide association study (EWAS) applied to educational research scans DNA methylation levels at hundreds of thousands of CpG sites across the genome to identify loci whose methylation is statistically associated with educational attainment, cognitive ability, or related learning outcomes. By linking blood- or saliva-derived methylation profiles with school records or psychometric scores, EWAS offers a molecular window into how biological and environmental exposures may shape educationally relevant traits across the lifespan. | Mediation analysis is a statistical procedure that tests whether the effect of an independent variable X on an outcome Y operates wholly or partly through a third variable M, called the mediator. Formalised by Baron and Kenny in 1986, it decomposes the total effect of X on Y into a direct path (c′) and an indirect path (a × b), quantifying how much of the relationship is carried by the mediating mechanism. |
| ScholarGateНабор от данни ↗ |
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