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| تحليل تسلسل الحمض النووي الريبوزي (RNA-seq) أحادي الخلية عبر الزمن× | تحليل eQTL× | |
|---|---|---|
| المجال | المعلوماتية الحيوية | المعلوماتية الحيوية |
| العائلة | Process / pipeline | Process / pipeline |
| سنة النشأة≠ | 2014-2018 (pseudotime and RNA velocity frameworks) | 2001 (term coined); widely adopted after 2005 |
| صاحب الطريقة≠ | Trapnell et al. (pseudotime/Monocle); La Manno et al. (RNA velocity) | Ritsert C. Jansen & Jan-Peter Nap |
| النوع≠ | Computational bioinformatics pipeline | Association mapping method |
| المصدر التأسيسي≠ | Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014). The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nature Biotechnology, 32(4), 381-386. DOI ↗ | Jansen, R. C., & Nap, J.-P. (2001). Genetical genomics: the added value from segregation. Trends in Genetics, 17(7), 388–391. DOI ↗ |
| الأسماء البديلة | scRNA-seq time course analysis, longitudinal scRNA-seq, temporal single-cell transcriptomics, dynamic single-cell gene expression analysis | eQTL mapping, expression QTL analysis, transcriptomic QTL analysis, eQTL study |
| ذات صلة | 6 | 6 |
| الملخص≠ | Time-series single-cell RNA-seq analysis captures gene expression across multiple time points at single-cell resolution to reveal how cell populations emerge, transition, and diverge during dynamic biological processes such as development, differentiation, or disease progression. By combining pseudotime ordering, RNA velocity, and differential dynamics testing, researchers reconstruct the temporal trajectory of individual cells and identify the gene regulatory changes that drive biological transitions. | eQTL analysis identifies genomic loci (variants, typically SNPs) whose genotype statistically associates with variation in the expression level of one or more genes. By jointly profiling DNA-level variation and RNA-level expression in the same individuals, eQTL studies decode the regulatory grammar of the genome — revealing which variants control how much a gene is transcribed, in which tissues, and under what conditions. |
| ScholarGateمجموعة البيانات ↗ |
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