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التورم والتحلل×التحليل الميكانيكي الديناميكي×الغزل الكهربائي×
المجالالمواد الحيويةالمواد الحيويةالمواد الحيوية
العائلةProcess / pipelineProcess / pipelineProcess / pipeline
سنة النشأة196019601934
صاحب الطريقةWichterle and LimFerry and SchwarzlAnton Formhals
النوعKinetic assayRheological characterizationFiber fabrication process
المصدر التأسيسيWichterle, O., & Lim, D. (1960). Hydrophilic gels for biological use. Nature, 185(4706), 117-118. DOI ↗Menard, K. P. (2008). Dynamic mechanical analysis: a practical introduction (2nd ed.). CRC Press. link ↗Formhals, A. (1934). Process and apparatus for preparing artificial threads. U.S. Patent 1,975,504. link ↗
الأسماء البديلةhydrogel swelling, polymer degradation, mass loss assayDMA, rheological analysis, viscoelastic testingelectrospun fiber production, electrostatic fiber spinning
ذات صلة433
الملخصThe swelling and degradation assay measures how biomaterial scaffolds absorb water (swelling) and lose mass over time due to degradation. Developed by Wichterle and Lim in 1960 for hydrogels, the assay is fundamental for characterizing hydrogels, synthetic polymers, and composite scaffolds intended for tissue engineering. The assay provides quantitative data on swelling kinetics (equilibrium water content, swelling ratio), degradation kinetics (mass loss rate, half-life), and mechanisms of degradation (chain scission, enzymatic breakdown).Dynamic mechanical analysis (DMA) measures the viscoelastic properties of materials—their elastic stiffness and viscous damping—by applying a sinusoidal stress or strain and measuring the phase lag and amplitude of the material's response. Developed from rheology principles in the 1960s and formalized by Ferry, Schwarzl, and others, DMA provides quantitative measures of how polymeric biomaterials respond to time-dependent and frequency-dependent mechanical stimuli. Key outputs include the storage modulus (elastic component), loss modulus (viscous component), and loss tangent (tan δ), which together characterize the material's mechanical behavior across temperature and frequency ranges.Electrospinning is an electrostatic fiber fabrication process that uses a high electric field to draw polymer solutions or melts into nanoscale fibers. Developed by Anton Formhals in the 1930s and refined by researchers including Darrell Reneker in the 1990s, the technique has become foundational to biomaterials engineering, enabling the creation of porous scaffolds for tissue engineering and drug delivery systems.
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ScholarGateقارن الطرق: Swelling and Degradation · Dynamic Mechanical Analysis · Electrospinning. استُرجع بتاريخ 2026-06-19 من https://scholargate.app/ar/compare