قارن الطرق
راجع الطرق التي اخترتها جنبًا إلى جنب؛ الصفوف المختلفة مميَّزة.
| تركيبة التشتت الصلب× | توصيل الأدوية عبر الجسيمات الشحمية× | |
|---|---|---|
| المجال | علم الأدوية | علم الأدوية |
| العائلة | Process / pipeline | Process / pipeline |
| سنة النشأة≠ | 1971 | 1965 |
| صاحب الطريقة≠ | William Chiou and Solomon Riegelman | Alec Bangham |
| النوع≠ | solubility enhancement | formulation technology |
| المصدر التأسيسي≠ | Chiou, W. L., Riegelman, S. (1971). Pharmaceutical applications of solid dispersions. Journal of Pharmaceutical Sciences, 60(9), 1281-1302. link ↗ | Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipid films and the determination of membrane potential. Journal of Molecular Biology, 13(1), 238-252. DOI ↗ |
| الأسماء البديلة | solid solution, amorphous dispersion, polymer-based formulation | liposomal formulation, vesicular delivery, lipid nanoparticles |
| ذات صلة | 3 | 3 |
| الملخص≠ | Solid dispersion is a formulation technique where a poorly soluble drug is molecularly dispersed in a hydrophilic polymer matrix, improving aqueous solubility and bioavailability. Introduced by Chiou and Riegelman in 1971, solid dispersions remain a key strategy for overcoming solubility-limited absorption. | Liposomal encapsulation is a formulation technique using lipid bilayer vesicles (liposomes) to enclose drugs, improving bioavailability, reducing toxicity, and enabling targeted delivery. Developed by Alec Bangham in 1965, liposomes are now standard in pharmaceutical development, with several FDA-approved liposomal drugs on the market. |
| ScholarGateمجموعة البيانات ↗ |
|
|