قارن الطرق

	معامل التشابه بالذوبان f1/f2	توصيل الأدوية عبر الجسيمات الشحمية
المجال	علم الأدوية	علم الأدوية
العائلة	Process / pipeline	Process / pipeline
سنة النشأة	1996	1965
صاحب الطريقة	James Moore and Hector Flanner	Alec Bangham
النوع	similarity testing	formulation technology
المصدر التأسيسي	Moore, J. W., & Flanner, H. H. (1996). Mathematical comparison of dissolution profiles. Pharmaceutical Technology, 20(6), 64-74.	Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipid films and the determination of membrane potential. Journal of Molecular Biology, 13(1), 238-252.
الأسماء البديلة	f1, f2, similarity factor	liposomal formulation, vesicular delivery, lipid nanoparticles
ذات صلة	3	3
الملخص	The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release.	Liposomal encapsulation is a formulation technique using lipid bilayer vesicles (liposomes) to enclose drugs, improving bioavailability, reducing toxicity, and enabling targeted delivery. Developed by Alec Bangham in 1965, liposomes are now standard in pharmaceutical development, with several FDA-approved liposomal drugs on the market.