قارن الطرق

	فحص نفاذية خلايا كـاكـو-2	الارتباط المختبري-الحيوي (In Vitro-In Vivo Correlation)
المجال	علم الأدوية	علم الأدوية
العائلة	Process / pipeline	Process / pipeline
سنة النشأة	1989	1995
صاحب الطريقة	Ingrid Hidalgo	Gordon Amidon
النوع	absorption screening	bioavailability prediction
المصدر التأسيسي	Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749.	Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413-420.
الأسماء البديلة	Caco-2 assay, intestinal permeability, ADME screening	IVIVC
ذات صلة	3	3
الملخص	The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport.	IVIVC is a mathematical relationship between in vitro and in vivo properties of a drug, developed to predict oral bioavailability from dissolution data. Introduced by Amidon and colleagues in the 1995 Biopharmaceutics Classification System, it bridges laboratory measurements and clinical outcomes to streamline drug development.