قارن الطرق

	القياس الدوائي الحرائكي الألومتري	الدوائية الحركية القائمة على الفسيولوجيا
المجال	علم الأدوية	علم الأدوية
العائلة	Process / pipeline	Process / pipeline
سنة النشأة	1989	1997
صاحب الطريقة	John Mordenti	Ivan Nestorov
النوع	inter-species extrapolation	predictive modeling
المصدر التأسيسي	Mordenti, J., & Chappell, W. (1989). The use of allometric scaling in toxicokinetic studies. Fundamental and Applied Toxicology, 13(2), 335-346.	Nestorov, I. (1997). Sensitivity analysis of pharmacokinetic and pharmacodynamic systems. Journal of Pharmacokinetics and Biopharmaceutics, 25(4), 529-543.
الأسماء البديلة	allometric scaling, inter-species extrapolation, FIH dose prediction	PBPK, PBPK modeling
ذات صلة	3	3
الملخص	Allometric scaling is a mathematical approach for predicting human pharmacokinetics from preclinical animal data using body weight relationships. Developed systematically by Mordenti and colleagues in the late 1980s, it enables rational first-in-human dose prediction without assuming species-specific metabolic differences.	PBPK is a mechanistic modeling framework that uses physiological parameters, tissue properties, and drug-specific attributes to predict drug concentration time profiles in the body. Developed rigorously in the 1990s by researchers including Nestorov, PBPK integrates anatomy, biochemistry, and kinetics to enable rational drug development, bridging in vitro data to clinical outcomes.