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PPI Network Topology/Ushahidi
Rekodi ya ushahidi wa mbinu

PPI Network Topology

Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations.

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Protein-Protein Interaction Network Analysis and Topology
Rekodi ya mbinu ya kiajenda · process-pipeline / bioinformatics
  • Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627. · DOI 10.1038/35001009
  • Barabási, A. L. & Oltvai, Z. N. (2004). Network biology: understanding the cell's functional organization. Nature Reviews Genetics, 5(2), 101-113. · DOI 10.1038/nrg1272
  • Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., ... & Mering, C. V. (2021). STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Research, 49(D1), D605-D612. · URL
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Same method familyCryo-EM Reconstructionmachine-suggested · Relational suggestion, not evidence.Same method familyHMMER Profile Searchmachine-suggested · Relational suggestion, not evidence.Same method familyMolecular Dockingmachine-suggested · Relational suggestion, not evidence.

Hali ya ushahidi

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

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