Salivary Biomarker Analysis
Salivary biomarker analysis detects protein, molecular, or microbial markers in saliva that indicate oral and systemic disease. Salivary diagnostics assess risk and activity of dental caries, periodontal disease, oral cancer, and other conditions. Biomarkers include antimicrobial proteins (lysozyme, lactoferrin), inflammatory mediators (interleukins, TNF-alpha), cariogenic bacteria (Streptococcus mutans), and virulence factors. Point-of-care saliva testing offers rapid, non-invasive alternatives to conventional laboratory methods, enabling chairside diagnosis and personalized risk assessment.
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- Giannobile, W. V., McDevitt, J. T., Niedbala, R. S., Malamud, D., & Prozorovsky, T. (2009). Translating molecular diagnostics into clinical practice: Designing the next generation of oral health technologies. Advances in Dental Research, 23(1), 80-89. · URL
- Siqueira, W. L., & Salih, E. (2012). Proteoglycans and proteomics in oral fluids: translating from the laboratory to clinical practice. Advances in Dental Research, 24(1), 74-77. · URL
- Devic, M., Glenski, M., Phelps, K., Lynch, T., & Brice, D. (2015). Use of salivary biomarkers in dentistry: A systematic review. Journal of Evidence-Based Dental Practice, 15(1), 1-11. · URL
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