Prospective Nested Case-Control
A prospective nested case-control study enrolls a cohort before disease onset, follows participants forward in time, and then — once cases develop — samples matched controls from those still at risk at the time each case occurs. By embedding the case-control comparison inside a prospective cohort, the design combines the causal clarity of longitudinal follow-up with the cost efficiency of analysing only a fraction of the cohort's stored specimens or records.
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- Thomas, D.C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. By F.D.K. Liddell, J.C. McDonald, and D.C. Thomas. Journal of the Royal Statistical Society, Series A, 140(4), 469-491. · URL
- Wacholder, S., McLaughlin, J.K., Silverman, D.T., & Mandel, J.S. (1992). Selection of controls in case-control studies: I. Principles. American Journal of Epidemiology, 135(9), 1019-1028. · DOI 10.1093/oxfordjournals.aje.a116396
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