Multicenter Nested Case-Control
A multicenter nested case-control study embeds a case-control analysis within two or more geographically or institutionally distinct prospective cohorts. Cases who develop the outcome of interest are identified across all participating sites, then matched to controls sampled from the same risk sets, enabling pooled estimation of exposure-disease associations with greater statistical power and geographic generalizability than any single-center nested design.
Kilderegister
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- Thomas, D.C. (1977). Addendum to: Methods of cohort analysis: appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. · URL
- Riboli, E., & Kaaks, R. (2002). The EPIC Project: Rationale and study design. International Journal of Epidemiology, 26(Suppl 1), S6–S14. · URL
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