Crossover Design
A crossover design is an experimental design in which each participant receives all treatments under investigation, but in a different sequence and across separate time periods. Each subject thus acts as their own control, which substantially reduces between-subject variability and allows efficient treatment comparisons with smaller sample sizes. The approach has been central to clinical pharmacology and comparative research since the mid-20th century, with foundational methodology codified by Senn (2002) and Jones & Kenward (2014).
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- Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. · ISBN 978-0471496533
- Jones, B. & Kenward, M. G. (2014). Design and Analysis of Cross-Over Trials (3rd ed.). CRC Press. · ISBN 978-1439861424
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