Adaptive Pretest-Posttest Experimental Design
An adaptive pretest-posttest experimental design measures all participants before and after an intervention while allowing pre-specified modifications to the trial — such as sample size re-estimation, treatment arm dropping, or randomization ratio adjustment — based on accumulated interim data. It combines the interpretive power of change-score analysis with the efficiency gains and ethical safeguards of adaptive methodology, making it particularly valuable in clinical, educational, and behavioral research where early data can inform better resource allocation.
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- Campbell, D. T., & Stanley, J. C. (1963). Experimental and Quasi-Experimental Designs for Research. Rand McNally. · URL
- Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. · ISBN 9781584888468
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