Mixture Design
Mixture experiment design is a class of constrained experimental design in which the factors are the proportions of components in a blend, subject to the constraint that all proportions sum to one. The framework was formalised by Henry Scheffé in 1958 and covers simplex-lattice, simplex-centroid, and D-optimal mixture designs widely used in pharmaceutical formulation, food science, and materials research.
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- Scheffé, H. (1958). Experiments with Mixtures. Journal of the Royal Statistical Society, Series B, 20(2), 344–360. · DOI 10.1111/j.2517-6161.1958.tb00299.x
- Cornell, J. A. (2002). Experiments with Mixtures: Designs, Models, and the Analysis of Mixture Data (3rd ed.). Wiley. · ISBN 978-0471393374
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