Functional Ultrasound
Functional Ultrasound (fUS) is a high-framerate Doppler ultrasound technique that dynamically maps blood flow and hemodynamic changes in vivo with millisecond temporal resolution. Pioneered by Tanter, Macé, and colleagues in the 2010s, fUS enables real-time imaging of microvascular perfusion in the brain and other organs. By combining ultrafast acquisition (1000-5000 frames per second) with Doppler processing, fUS reveals functional activity (hemodynamic changes during stimulation or behavior) and vascular networks with unprecedented spatiotemporal detail.
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- Macé, E., Montaldo, G., Trenholm, S., et al. (2011). Functional ultrasound imaging of the brain. Nature Methods, 8(8), 662-664. · DOI 10.1038/nmeth.1641
- Tiran, E., Sieu, L. A., Bergel, A., et al. (2017). Multiplane wave imaging increases signal awareness for small vasculature imaging in mice and rats. IEEE Transactions on Medical Imaging, 36(11), 2371-2379. · URL
- Errico, C., Pierre, J., Pezet, S., et al. (2015). Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature, 527(7579), 499-502. · DOI 10.1038/nature16066
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