Alzheimer's Disease Assessment Scale-Cognitive
The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) is a clinician-administered cognitive assessment instrument designed specifically to measure cognitive decline in Alzheimer's disease. Developed by Rosen, Mohs, and Davis in 1984 and published in the American Journal of Psychiatry, the ADAS-Cog has become the gold standard outcome measure in pharmaceutical trials of antidementia drugs. It is sensitive to disease progression and capable of detecting cognitive change over periods as brief as 6–12 months.
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- Rosen, W. G., Mohs, R. C., & Davis, K. L. (1984). A new rating scale for Alzheimer's disease. American Journal of Psychiatry, 141(11), 1356-1364. · DOI 10.1176/ajp.141.11.1356
- Mohs, R. C., Knopman, D., Petersen, R. C., et al. (1997). Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the ADAS and MMSE. Alzheimer Disease and Associated Disorders, 11(Suppl 2), 13-21. · URL
- Pfeffer, R. I., Inoue, S. K., & Chance, G. R. (2000). Diagnostic criteria for dementia: Revision of the DSM-IV and ICD-10. Journal of the American Geriatrics Society, 48(12), 1572-1578. · URL
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