Risk-adjusted case-crossover design
The risk-adjusted case-crossover design is a self-matched epidemiological method that compares a person's exposure during a brief hazard window immediately preceding an acute event to their exposure during one or more control windows from the same individual, while formally accounting for time-varying or time-fixed covariates that could confound the exposure-event relationship. By using each case as their own control, stable individual-level confounders are automatically cancelled, while covariate adjustment handles residual time-varying risks.
Allikakirje
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- Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. · DOI 10.1093/oxfordjournals.aje.a115853
- Navidi, W. (1998). Bidirectional case-crossover designs for exposures with time trends. Biometrics, 54(2), 596–605. · DOI 10.2307/3109766
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