Crossover multi-arm experiment
A crossover multi-arm experiment is a within-subject experimental design in which each participant receives three or more treatments (arms) across successive periods, with random assignment to sequence. Because every participant experiences all arms, the design eliminates between-subject variability from treatment comparisons, dramatically increasing statistical power for a given sample size. It is widely used in clinical pharmacology, psychology, agriculture, and behavioral research.
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- Jones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. · ISBN 978-1584883869
- Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. · ISBN 978-0471496533
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