Registro de evidencia del método

Sequential Design

Sequential and group sequential trial designs allow a study to be stopped early — or continued — based on interim analyses conducted as data accumulate. The core framework was formalised by O'Brien and Fleming in 1979 and extended by Lan and DeMets's alpha-spending approach, and it controls the overall Type I error rate across all planned looks by pre-specifying both efficacy and futility boundaries before enrolment begins.

Sources recorded, not reviewed

Registro de origen

Citas copiadas textualmente del registro de origen del método. No se infiere ninguna verificación a nivel de afirmación de ellas.

Sequential / Group Sequential Trial Design

Registro del método taxonómico · hypothesis-test / experimental-design

O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556. · DOI 10.2307/2530245
Jennison, C. & Turnbull, B.W. (2000). Group Sequential Methods with Applications to Clinical Trials. CRC Press. · ISBN 978-0849303166

Abrir método completo

Afirmaciones curadas

Afirmaciones persistidas en el libro mayor de evidencia, cada una con su propia evaluación.

Aún no hay afirmaciones curadas

Esta vista no inventa una evaluación de afirmación si el libro mayor no tiene ninguna.

Métodos relacionados

Generado a partir del grafo de métodos y mostrado como relaciones sugeridas por la máquina; no se infiere ninguna afirmación de evidencia.

Same method familyAdaptive Clinical Trial Designmachine-suggested · Relational suggestion, not evidence.Same method familyPower analysismachine-suggested · Relational suggestion, not evidence.Same method familyRandomized Controlled Trialmachine-suggested · Relational suggestion, not evidence.