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| Σύνθεση Στερεής Διασποράς× | Δοκιμασία Διαπερατότητας Κυττάρων Caco-2× | |
|---|---|---|
| Πεδίο | Φαρμακολογία | Φαρμακολογία |
| Οικογένεια | Process / pipeline | Process / pipeline |
| Έτος προέλευσης≠ | 1971 | 1989 |
| Δημιουργός≠ | William Chiou and Solomon Riegelman | Ingrid Hidalgo |
| Τύπος≠ | solubility enhancement | absorption screening |
| Θεμελιώδης πηγή≠ | Chiou, W. L., Riegelman, S. (1971). Pharmaceutical applications of solid dispersions. Journal of Pharmaceutical Sciences, 60(9), 1281-1302. link ↗ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ |
| Εναλλακτικές ονομασίες | solid solution, amorphous dispersion, polymer-based formulation | Caco-2 assay, intestinal permeability, ADME screening |
| Συναφείς | 3 | 3 |
| Σύνοψη≠ | Solid dispersion is a formulation technique where a poorly soluble drug is molecularly dispersed in a hydrophilic polymer matrix, improving aqueous solubility and bioavailability. Introduced by Chiou and Riegelman in 1971, solid dispersions remain a key strategy for overcoming solubility-limited absorption. | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. |
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