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| Φαρμακομεταφορείς λιποσωμάτων× | Δοκιμασία Διαπερατότητας Κυττάρων Caco-2× | |
|---|---|---|
| Πεδίο | Φαρμακολογία | Φαρμακολογία |
| Οικογένεια | Process / pipeline | Process / pipeline |
| Έτος προέλευσης≠ | 1965 | 1989 |
| Δημιουργός≠ | Alec Bangham | Ingrid Hidalgo |
| Τύπος≠ | formulation technology | absorption screening |
| Θεμελιώδης πηγή≠ | Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipid films and the determination of membrane potential. Journal of Molecular Biology, 13(1), 238-252. DOI ↗ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ |
| Εναλλακτικές ονομασίες | liposomal formulation, vesicular delivery, lipid nanoparticles | Caco-2 assay, intestinal permeability, ADME screening |
| Συναφείς | 3 | 3 |
| Σύνοψη≠ | Liposomal encapsulation is a formulation technique using lipid bilayer vesicles (liposomes) to enclose drugs, improving bioavailability, reducing toxicity, and enabling targeted delivery. Developed by Alec Bangham in 1965, liposomes are now standard in pharmaceutical development, with several FDA-approved liposomal drugs on the market. | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. |
| ScholarGateΣύνολο δεδομένων ↗ |
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