Σύγκριση μεθόδων

	COSY	NOESY
Πεδίο	Φασματοσκοπία	Φασματοσκοπία
Οικογένεια	Process / pipeline	Process / pipeline
Έτος προέλευσης	1976	1981
Δημιουργός	Wüthrich Kurt	Richard Ernst
Τύπος	Two-dimensional pulse sequence	Two-dimensional pulse sequence
Θεμελιώδης πηγή	Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246.	Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246.
Εναλλακτικές ονομασίες	COSY NMR, 2D COSY, 1H-1H COSY	NOE spectroscopy, 2D NOESY, NOE NMR
Συναφείς	4	3
Σύνοψη	Correlation Spectroscopy (COSY) is a two-dimensional NMR technique that correlates proton chemical shifts through scalar coupling (J-coupling), revealing which protons are magnetically coupled and hence bonded through multiple bonds. Developed by Aue, Bartholdi, and Ernst in 1976, COSY became one of the most important tools in structural elucidation, enabling chemists to map out proton connectivity patterns and deduce molecular topology without isotopic labeling.	Nuclear Overhauser Enhancement Spectroscopy (NOESY) is a 2D NMR technique that detects through-space dipolar coupling between protons, rather than through-bond scalar coupling. Introduced by Macura and Ernst in 1981, NOESY reveals which protons are spatially close in the three-dimensional structure, independent of bonding connectivity. This makes NOESY invaluable for determining molecular conformation, assigning stereochemistry, and elucidating protein folds.